Ivan Aprahamian
Professor
Appointments
Chair, Department of Chemistry
Professor of Chemistry
Area of Expertise
Molecular switches and machines ,
organic chemistry,
Supramolecular chemistry,
Photochemistry,
Adaptive materials,
Photopharmacology
Biography
The Aprahamian group uses modular and tunable hydrazone-based building blocks in the development of molecular switches, fluorophores, sensors and adaptive materials. To this end we usesynthetic, physical organic, and supramolecular chemistry in conjunction with advanced spectroscopic methods.
Our interest in controlling molecular motion and converting it into mechanical work has resulted in the development of new hydrazone-based molecular switches that can be activated either chemically or photochemically. These novel systems are expected to form the basis of various molecular machines and motors that can be used in applications ranging from drug delivery to energy storage.
The group is also developing new hydrazone-based fluorophores that can be used in sensing, bio-imaging, and energy applications, among others.
Education
B.Sc. The Hebrew University of Jerusalem
M.Sc. The Hebrew University of Jerusalem
Ph.D. The Hebrew University of Jerusalem
Publications
1) B. Balamut, R. Hughes, I. Aprahamian, Tuning the Properties of Hydrazone/Isosorbide-Based Switchable Chiral Dopants, J. Am. Chem. Soc. 2024, 146, 24561–24569
2) Q. Qi, J. T. Plank, A. R. Lippert, I. Aprahamian, A photoswitchable handheld volumetric 3D display, Chem 2024, 10, 1–11
Highlighted in Dartmouth News, Chemistry World and others
3) B. Shao, H. Fu, I. Aprahamian, A molecular anion pump, Science 2024, 385, 544–549
Highlighted in Dartmouth News, MSN, Smart Water Magazine and others
4) Q. Qi, S. Huang, X. Liu, I. Aprahamian, 1,2-BF2 Shift and Photoisomerization Induced Multichromatic Response, J. Am. Chem. Soc. 2024, 146, 6471–6475
5) G. C. Thaggard, K. C. Park, J. Lim, B. K. P. M. Kankanamalage, J. Haimerl, G. R. Wilson, M. K. McBride, K. L. Forrester, E. R. Adelson, V. S. Arnold, S. T. Wetthasinghe, V. A. Rassolov, M. D. Smith, D. Sosnin, I. Aprahamian, M. Karmakar, S. K. Bag, A. Thakur, M. Zhang, B. Z. Tang, J. A. Castaño, M. N. Chaur, M. M. Lerch, R. A. Fischer, J. Aizenberg, R. Herges, J.-M. Lehn & N. B. Shustova, Breaking the photoswitch speed limit, Nat. Comm. 2023, 14, 7556
6) H. Fu, S. Pramanik, I. Aprahamian, Metal and Proton Relay-Controlled Hierarchical Multistep Switching Cascade, J. Am Chem. Soc. 2023, 145, 19554–19560
7) Q. Qiu, Q. Qi, J. Usuba, K. Lee, I. Aprahamian, G. G. D. Han, Visible Light Activated Energy Storage in Solid-State Azo-BF2 Switches, Chem. Sci. 2023, 14, 11359–11364
Highligthed as part of the 2023 Chemical Science HOT Article Collection
8) I. Aprahamian, S. M. Goldup, Non-equilibrium Steady States in Catalysis, Molecular Motors, and Supramolecular Materials: Why Networks and Language Matter, J. Am Chem. Soc. 2023, 145, 14169–14183
9) G. C. Thaggard, G. A. Leith, D. Sosnin, C. R. Martin, K. C. Park, M. K. McBride, J. Lim, B. J. Yarbrough, B. K. P. M. Kankanamalage, G. R. Wilson, A. R. Hill, M. D. Smith, S. Garashchuk, A. B. Greytak, I. Aprahamian, N. B. Shustova, Confinement-Driven Photophysics in Hydrazone-Based Hierarchical Materials, Angew. Chem. Int. Ed. 2022, e202211776
Selected as Very Important Paper
10) Q. Qiu, S. Yang, M. A. Gerkman, H. Fu, I. Aprahamian, G. G. D. Han, Photon Energy Storage in Strained Cyclic Hydrazones: Emerging Molecular Solar Thermal Energy Storage Compounds J. Am. Chem. Soc., 2022, 144, 12627–12631
11) B. Shao, I. Aprahamian, Hydrazones as New Molecular Tools, Chem 2020, 6, 2162-2173
12) I. Aprahamian, The Future of Molecular Machines, ACS Cent. Sci. 2020, 6, 347–358
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